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КОМБИНАЦИЯ МАКРОЦИКЛИЧЕСКОГО ИНГИБИТОРА ПРОТЕАЗЫ HCV, НЕНУКЛЕОЗИДНОГО ИНГИБИТОРА HCV И РИТОНАВИРА
专利权人:
ЯНССЕН ФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
РУАН Мари-Клод (FR),СНУЙС Ян (BE)
申请号:
RU2015111491
公开号:
RU2015111491A
申请日:
2013.08.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A combination comprising (i) a compound of formula I or a pharmaceutically acceptable salt thereof, (ii) a compound of formula IIili a pharmaceutically acceptable salt thereof and (iii) a compound of formula III, or a pharmaceutically acceptable salt thereof, characterized in that the amount of Formula I compound is about from 25 to 100 mg, the amount of compound II is from about 10 to 50 mg and the amount of the compound of formula III is from about 100 to 750 mg.2. Combination according to Claim. 1, characterized in that the amount of compound II is from about 15 to 30 mg.3. Combination according to Claim. 1, characterized in that the amount of Formula I compound ranges from about 40 to 80 mg.4. A combination according to claim. 2, characterized in that the amount of Formula I compound ranges from about 40 to 80 mg.5. Combination according to Claim. 1, characterized in that the amount of the compound of formula III is approximately 200-600 mg.6. A combination according to claim. 2, characterized in that the amount of the compound of formula III is approximately 200-600 mg.7. A combination according to para. 3, characterized in that the amount of the compound of formula III is approximately 200-600 mg.8. Combination according to Claim. 1, characterized in that the amount of Formula I compound is about 75 mg, the amount of compound II is about 25 mg and the amount of the compound of formula III is approximately 300 mg.9. Combination according to Claim. 1 further comprising another antiviral agent against HCV, selected from HCV polymerase inhibitors, HCV protease inhibitor, an inhibitor of another target in the HCV life cycle, and immunomodulatory agent, an antiviral agent and kombinatsii.10. A product comprising a compound of formula I, II and the compound of formula III, all of which are defined in claim. 1, in the form of1. Комбинация, включающая (i) соединение формулы Iили его фармацевтически приемлемую соль,(ii) соединение формулы IIили его фармацевтически пр
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