A sterilization system and method for the sterilization of medical and dental instruments, handpieces and burrs, tools and devices. Such a sterilization system and method compress hot air in the sterilization chamber with specific pressure and temperature values along specific interval of time to perform sterilization process. The sterilization system includes an air filter, a compressor, inlet solenoid valve, a heat exchanger, a sterilization chamber, an outlet aperture, and an outlet solenoid valve.