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METHODS FOR ENHANCING IMMUNE RESPONSE
专利权人:
Lankenau Institute For Medical Research;Aminex Therapeutics
发明人:
Mark R. Burns,Susan K. Gilmour,Thomas G. O'Brien,Thomas G. OBrien
申请号:
US14531153
公开号:
US20150050299A1
申请日:
2014.11.03
申请国别(地区):
US
年份:
2015
代理人:
摘要:
This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
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中国工程科技知识中心
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