Lankenau Institute For Medical Research;Aminex Therapeutics
发明人:
Mark R. Burns,Susan K. Gilmour,Thomas G. O'Brien,Thomas G. OBrien
申请号：
US14531153
公开号：
US20150050299A1
申请日:
2014.11.03
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including； bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
