Systems and methods are disclosed for assessing a risk of disease. One method includes obtaining an anatomic model associated with a target anatomy； modeling, using a processor, an injection of one or more virtual contrast agents into the anatomic model； performing a simulation of flow of blood and the one or more virtual contrast agents through the anatomic model； and computing one or more characteristics of concentration associated with the one or more virtual contrast agents at one or more locations in the anatomic model based on the simulation.
