VAP-1/SSAO activity inhibitors and pharmaceutical compositions containing the same are useful for treating headache, chronic migraine, recurrent migraine, substance abuse headache disorder (MOU), migraine without aura, migraine with aura, headache. Useful for the prevention and/or treatment of migraine including aura, migraine vestibular, vestibular migraine, basilar migraine, hemiplegic migraine, migraine ophthalmoplegia, tension headache (TTH) is there.ＶＡＰ－１／ＳＳＡＯ活性阻害剤及びそれを含む医薬組成物は、頭痛、慢性片頭痛、反復性片頭痛、薬物乱用頭痛障害（ＭＯＵ）、前兆のない片頭痛、前兆のある片頭痛、頭痛のない片頭痛前兆、眼性片頭痛、前庭片頭痛、脳底片頭痛、片麻痺性片頭痛、眼筋麻痺性片頭痛、緊張型頭痛（ＴＴＨ）を含む片頭痛の予防及び／又は処置に有用である。
