CHATURVEDULA Prasad V.,CHATURVEDULA Prasad V.,DUBOWCHIK Gene M.,DUBOWCHIK Gene M.,MACOR John E.,MACOR John E.
申请号：
SI201130765
公开号：
SI2552906T1
申请日:
2011.03.11
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
The disclosure generally relates to the compound of formula I, (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide, including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.
