The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.本發明提供一種新穎類別之化合物、包含該等化合物之醫藥組合物,及使用該等化合物治療或預防與異常或失調激酶活性相關之疾病或病症、尤其涉及B-Raf異常活化之疾病或病症的方法。(無元件符號說明)