Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof

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专利权人:

Thomas J. Kipps

发明人:

Thomas J. Kipps,Jianqiang Yu

申请号：

US13703864

公开号：

US09242014B2

申请日:

2011.06.15

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/