The present invention relates generally to immunogenic conjugates, antigen and the fusion of substance and integrative nucleic acid monomer and its this combination of coding including at least five antigen mycobacterias. The present invention also relates to nucleic acid molecules, carrier, host cell and composition include or encode it is described combination antigen of mycobacterium fused polypeptide method and for recombinant production they. The present invention also relates to use the combination antigen of mycobacterium, fused polypeptide, carrier, host cell, the method that composition especially induced or stimulated immune response mycobacterial infections or any associated mycobacterial infections of disease caused by. The present invention also relates to the antibody and fused polypeptide that are directed to this antigen of mycobacterium, such as include the combined antigen of mycobacterium, fused polypeptide, carrier, host cell, composition or antibody for the method for detection of diagnosis of mycobacterial infections and the reagent of kit.
