The present invention discloses a high density retinal prosthesis system with equalization comprises a retinal prosthesis chip, a measuring device, a tuning device, and a transmitting device. After the measuring device capable of generating electrical induction with the retinal prosthesis chip obtains a degree of light stimulation received by pixel units in the retinal prosthesis chip, it is equalized by the tuning device, and then a calibration signal is fed to the pixel units to tune the pixel units to make the pixel units in the retinal prosthesis system to achieve an equalization effect.