A liposome composition of naproxen and excipients comprises 15 -25% by weight of phospholipids in form of calibrated aggregates in conjunction with double alcohol, in mass proportion from 0.6:1 to 1.67:1. Preferably the concentration of naproxen is 10% by weight. The phospholipid is phosphatidylcholine. Excipients are: antioxidant, preserving agent, buffering agents, local blood perfusion-enhancing agents, and gelling agent. A method of obtaining the said composition is also disclosed.