1 compound of formula and its pharmaceutically acceptable salt are disclosed, wherein G, L1, L2, R1, R2, R3 and R4 are defined in. Present disclosure also relates to the material and method of 1 compound of what preparation formula, the pharmaceutical composition comprising 1 compound of formula and they with what treatment be related to illness, the purposes of disease and symptom of immune system and inflammation, the illness, disease and symptom include rheumatoid arthritis, malignant hematologic disease, epithelioma (that is, cancer) and the other illnesss, disease and the symptom that need to inhibit SYK.公開了式1化合物和其藥學上可接受的鹽，其中G、L1、L2、R1、R2、R3和R4在說明書中定義。本公開還涉及用於製備式1化合物的材料和方法、包含式1化合物的藥物組合物和它們用於治療涉及免疫系統和炎症的病症、疾病和病狀的用途，所述病症、疾病和病狀包括類風濕性關節炎、惡性血液病、上皮癌(即，癌症)和需要抑制SYK的其它病症、疾病和病狀。
