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PROCÉDÉ DE PRÉPARATION D'UNE COMPOSITION PHARMACEUTIQUE COMPRENANT UN DÉRIVÉ DE QUINOLÉINE OU UN SEL DE CELUI-CI
专利权人:
Jiangsu Hengrui Medicine Co.; Ltd.
发明人:
申请号:
EP17743703.5
公开号:
EP3378479A1
申请日:
2017.01.23
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention provides a method for preparing a pharmaceutical composition comprising a quinoline derivative or a salt thereof. Specifically, the invention provides a method for preparing a pharmaceutical composition comprising an (R,E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)-propeneamide or a pharmaceutically acceptable salt thereof. The method comprises using a wetting agent comprising at least one organic solvent for a wet granulation in a preparation process of the pharmaceutical composition. The pharmaceutical composition prepared using the method has a uniform distribution of grain sizes during the preparation process and a property of rapid and uniform dissolution.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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