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FORMULATION DE SOLUTION DE PROTEINES STABLE CONTENANT UNE FORTE CONCENTRATION D'UN ANTICORPS ANTI-VEGF
专利权人:
NOVARTIS AG
发明人:
ZHANG, HUIXIANG,BORING, CHARLES,KULSHRESHTHA, ALOK,ZENG, YUHONG,WAN, LI,ALANI, LAMAN
申请号:
CA2966758
公开号:
CA2966758A1
申请日:
2015.11.06
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection, preferably an intravitreal injection. The aqueous pharmaceutical compositions are useful for delivery of a high concentration of the antibody active ingredient to a patient without high levels of antibody aggregation and without a high level of sub-visible particulate matter. An aqueous composition of the invention comprises an antibody having a concentration of at least 50 mg/ml. An aqueous pharmaceutical composition of the invention includes a sugar, a buffering agent, and a surfactant.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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