COMPOSES HETEROCYCLIQUES SUBSTITUES PAR UNE AMINE UTILISES COMME INHIBITEURS DE L'EHMT2 ET LEURS METHODES D'UTILISATION

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专利权人:

INC.;EPIZYME

发明人:

CAMPBELL, JOHN EMMERSON,DUNCAN, KENNETH WILLIAM

申请号：

CA3045032

公开号：

CA3045032A1

申请日:

2017.12.19

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

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