FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE NAUKI INSTITUT PROBLEM KHIMICHESKOJ FIZIKI RAN(IPKHF RAN)
发明人:
KORNEV ALEKSEJ BORISOVICH,Корнев Алексей Борисович,TROSHIN PAVEL ANATOLEVICH,Трошин Павел Анатольевич
申请号：
RU2012129528/05
公开号：
RU0002567299C2
申请日:
2012.07.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to chemical and pharmaceutical industries, and concerns chemical functionalisation of fullerene C60, particularly a method for organic fullerene [60] derivative synthesis, including soluble in water and physiological media. A problem of producing high-stable polycarboxyl fullerene C60 derivatives applicable in biomedicine or pharmacology, as well as for producing fullerene derivative conjugates with other medicinal preparations is solved within the invention by creating a new class of arylated polycarboxyl fullerene C60 derivatives containing aromatic carboxylic acid (carboxylic acid derivatives) fragments attached to a fullerene frame, as well as a method for producing these compounds. The invention defends structures and a method for producing a particular class of polycarboxyl arylated fullerene C60 derivatives having a composition and structure described by general formula 1, namely . The invention also refers to a method for producing the compounds described by general formula 1, by means of conducting a reaction of fullerene C60 halogen derivatives with protected derivatives of aromatic carboxylic acids in the presence of Lewis acids as a catalyst. The polycarboxyl compounds are further produced in the form of free acids by acid hydrolysis. .EFFECT: invention can find application in biomedical investigations and manufacturing of new medicinal preparations applicable for therapy of human and animal diseases more specifically, the invention refers to new arylated polycarboxyl fullerene C60 derivatives and a method for producing them.9 cl, 4 dwg, 2 tblИзобретение относится к химической и фармацевтической отраслям промышленности и касается химической функционализации фуллерена C60, в частности метода синтеза органических производных [60] фуллерена, в том числе растворимых в воде и физиологических средах. Проблема получения высокостабильных поликарбоксильных производных фуллерена C60, пригодных для использо
