The invention provides methods to treating an obstructed biological conduit,that include administering to the conduit an agent that can degradeextracellular matrix of obstructing tissue. Particular methods includedelivery of an enzyme or a mixture of several enzymes to the area or region ofobstruction wherein the enzyme(s) have the capability to degrade extracellularmatrix components within the obstruction thereby restoring the normal flow oftransported fluid through the conduit. The invention also includespreventively dilating a section of conduit to minimize the risk of obstructionformation.
