University of Pittsburgh—Of the Commonwealth System of Higher Education
发明人:
Liu Yang,Pham Hoa Vinh,Fnu Shikhar
申请号：
US201615055222
公开号：
US9983399(B2)
申请日:
2016.02.26
申请国别(地区):
美国
年份:
2018
代理人:
Eckert Seamans Cherin & Mellott, LLC `Levy Philip E.
摘要：
Provided are systems, methods, and other embodiments associated with depth-resolved spatial-domain low-coherence quantitative phase microscopy for high-throughput analysis of 3D nanoscale architectural alterations in unstained tissue and cells. A spatial-domain low-coherence quantitative phase microscopy apparatus includes a drOPD mapping module, a transmission phase imaging module, and a bright-field and transmission phase imaging module. The drOPD mapping module includes a reflection-mode low-coherence spectral interferometry for drOPD mapping of unstained tissue. The transmission phase imaging module includes transmission quantitative phase imaging of unstained and stained tissue and produce an image registration reference. The bright-field and transmission phase imaging module includes bright-field imaging of H&E-stained tissue for nuclei identification and pathology correlation.
