BERTHET, FRANCOIS-XAVIER JACQUES,DALEMANS, WILFRIED L. J.,DENOEL, PHILIPPE,DEQUESNE, GUY,FERON, CHRISTIANE,LOBET, YVES,POOLMAN, JAN,THIRY, GEORGES,THONNARD, JOELLE,VOET, PIERRE
申请号：
CA2380840
公开号：
CA2380840C
申请日:
2000.07.31
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paedi-atric use. Examples of the Gram-negative strains from which the blebs are madeare N. meningitidis, M. catarrhalis and H. influenzae.The blebs of the invention are improved by one or more genetic changes to thechromosome of the bacterium, including up-regulationof protective antigens, down-regulation of immunodominant non-protectiveantigens, and detoxification of the Lipid A moiety ofLPS.
