NRC 49.1160100.4i . l aitib 02 -it- Mil 102 10.3 104 104 10 10-7 o 0 4 0.0 10 NR (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIP0 I PCT o mum °nolo UI n ono oimIE (10) International Publication Number WO 2018/175833 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/18 (2006.01) A61K 39/00 (2006.01) C07K 16/28 (2006.01) A61K 45/06 (2006.01) C07K 14/00 (2006.01) (21) International Application Number: PCT/US2018/023927 (22) International Filing Date: 23 March 2018 (23.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/475,573 23 March 2017 (23.03.2017) US (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]； 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: SONG, Wenchao； 213 Cornell Drive, Bryn Mawr, PA 19010 (US). MIWA, Takashi； 191 Presiden- tial Blvd., Unit 323, Bala Cynwyd, PA 19004 (US). SA- TO, Sayaka； 2130 Locust Street, Apt. #A1, Philadelphia, PA 19103 (US). GULLIPALLI, Damodar； 4007 Wood- land Avenue, Apt. B, Philadelphia, PA 19106 (US). (74) Agent: HAAS, Dennis, L. et al.； Riverside Law, LLP, Glenhardie Corporate Center, 1285 Drummers Lane, Suite 202, Wayne, PA 19087 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (un
