Also provided are Pharmaceutical compositions comprising these Antibodies, Nucleic Acids encoding these Antibodies,Expression Vectors and host cells to produce these Antibodies, and Methods for treating a subject using these Antibodies.Claim 1: isolated an Antibody that binds specifically to Human tim-3,The Antibody comprises a variable region of heavy chain complementarity determining regions comprising cdrh1,Cdrh2 and cdrh3 and a variable region of light chain complementarity determining regions comprising cdrl1, cdrl2 and cdrl3,Where: (a) cdrh1 comprises the amino acid sequence of x\u00b9x\u00b2x\u00b3x\u2074x\u2075s (SEQ ID no. 48), which is x\u00b9 R, S, a, G, or t x K, M, Q, S, r, G, or t, X is n, and G Is x\u2074 or Q, or x\u2075 is Q and W, a, M,S or t (b) cdrh2 comprises the amino acid sequence of wvsaisgsggsty (SEQ ID no. 2) (c) cdrh3 comprises the amino acid sequence of akggdyggnyfd (SEQ ID no. 3) (d) cdrl1 comprises the sequenceAmino Acid x\u00b9asqsvx\u00b2ssyla (SEQ ID no. 52), where x\u00b9 is R or g, and X is absent or is s (e) cdrl2 comprises the amino acid sequence of x\u00b9asx\u00b2rat (SEQ ID no. 53), where x\u00b9 is d or g, and X is n,S or t and (f) cdrl3 comprises the amino acid sequence of qqygsspx\u00b9t (SEQ ID no. 54), where X1 is l or R.También se proporcionan composiciones farmacéuticas que comprenden estos anticuerpos, ácidos nucleicos que codifican estos anticuerpos, vectores de expresión y células hospedadoras para producir estos anticuerpos, y métodos para tratar a un sujeto usando estos anticuerpos. Reivindicación 1: Un anticuerpo aislado que se une de forma especifica a TIM-3 humano, el anticuerpo comprende una región variable de cadena pesada que comprende regiones determinantes de complementariedad CDRH1, CDRH2 y CDRH3 y una región variable de cadena ligera que comprende regiones determinantes de complementariedad CDRL1, CDRL2 y CDRL3, donde: (a) CDRH1 comprende la secuencia de aminoácidos de X¹X²X³X⁴X⁵S (SEQ ID Nº 48), donde X¹
