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Methods of making l-ornithine phenyl acetate
专利权人:
OCERA THERAPEUTICS INC.
发明人:
ANDERSON KEITH H.,BEHLING JIM,DOUGAN CHRISTINE HENDERSON,WATT STEPHEN WILLIAM,MANINI PETER,FIGINI ATTILIA
申请号:
NZ60919111
公开号:
NZ609191A
申请日:
2011.10.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Disclosed is a process for making L-ornithine phenyl acetate salt (V) comprising: preparing a solution of phenyl acetate salt by mixing a phenyl acetic acid and a base in a solvent; intermixing L-ornithine benzoate with the above solution; isolating a composition comprising L-ornithine phenyl acetate. The process may include forming an L-ornithine benzoate salt intermediate. The process may also include intermixing a halide salt of L-ornithine with silver phenyl acetate. The present application also relates to various compositions obtained from these processes, including crystalline forms.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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