The invention provides novel adjuvants and pharmaceutical compositioncomprising of an adjuvant alone. The inventionalso provides novel vaccine compositions comprising of an antigen and a noveladjuvant. The novel adjuvant as perpresent invention is farnesoid-X-receptor (FXR) antagonist. The invention alsorelates to an adjuvant for variety of antigens. Theadjuvant improves antibody production specific to incorporated antigen. Theadjuvant also induces cell mediated immune response.