A device system and method for tumor detection and/or monitoring is proposed. The proposed device comprises a first analysis unit (34) for analyzing the spatial distribution of the photoplethysmographic PPG amplitude of PPG signals obtained from a region of interest a second analysis unit (36) for analyzing the spatial distribution of arterial blood oxygen saturation obtained from said PPG signals and an evaluation unit (38) for detecting and/or monitoring a tumor in said region of interest based on said two analyses.
