Cell penetrating peptide conjugates for delivering nucleic acids into cells

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专利权人:

Cellectis

发明人:

Alluis, Bertrand,Fruchart, Jean-Sebastien

申请号：

AU2006325030

公开号：

AU2006325030B2

申请日:

2006.12.15

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The invention provides cell penetrating peptide-nucleic acid conjugates havingthe formula P- L-N, wherein P is a cell penetrating peptide, N is a nucleic acid,preferably an oligonucleotide and more preferably a siRNA, and L is a hydrophilicpolymer, preferably a polyethylene glycol (PEG)-based linker linking P andN together. Compositions, methods of use and methods for producing such conjugatesare also disclosed.

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