A syringe for the injection of an active substance and for the secondary injection of a medium, the syringe having a cylindrical syringe body with a limiting wall provided in the distal region, which transitions into a neck, two mechanically connected plungers that are axially displaceable in the syringe body, and a first actuating element for mutual displacement of the plungers, wherein, prior to the injection of the active substance, the distal plunger and the limiting wall delimit a first volume that is filled with the active substance, and mutually facing inner surfaces of the plungers delimit a second volume that is filled with the medium, wherein the plungers are displaced as a mechanically coupled unit by the application of force of the first actuating element in the direction of the limiting wall until the distal plunger comes to rest against the limiting wall or a stop.
