JASON R. HARRIS,QING XU,ZHE LI,BRIAN W. METCALF,STEPHEN L. GWALTNEY,CALVIN W. YEE
申请号：
ARP140101045
公开号：
AR095341A1
申请日:
2014.03.14
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Provide the appropriate Pharmaceutical compounds and compositions as modulators of hemoglobin, Methods and Intermediates for their preparation, and Methods for their use in the treatment of disorders mediated by hemoglobin and disorders that could benefit from the Oxygenation. Nisoldipine and \/ or cell. Antithrombotic Agent.Claim 1: a compound of formula (1) or a taut\u00f3mero thereof, or a pharmaceutically acceptable Salt of each of them, characterized in that: the ring is a heteroaryl 5-10 members optionally substituted Atoms containing up to 3 n, o, s and \/ or RingOxidized forms of N and S Atoms and \/ or, where the ring is replaced with a or B and the substitutionary relationship The Ring B is an optionally substituted aryl or Heterocyclic c\u2086\u208b\u2081\u2080 4 to 5 to 10 members containing hetero Atoms of the ring, where the Atom is SEL Eccionado among the group consisting of o, N, S,And the oxidized forms of N and S each is independently cr\u00b9\u2070r\u00b9\u00b9 y and Z, or s, so, or SO\u2082 nr\u00b9\u00b2 each r\u00b9\u2070 and r\u00b9\u00b9 independently Hydrogen or optionally substituted alkyl c\u2081\u208b\u2083, Halo, Oh, or alkoxy, or cr\u00b9\u2070r\u00b9\u00b9 is c = o r\u00b9\u00b2 c\u2081\u208b\u2086 Siem is Hydrogen or alkyl. Pre if one of y and Z is o, S, so, SO\u2082, then the other is not coAnd always that y and Z are both heteroatoms or oxidized forms of the same The C ring is optionally substituted aryl and c\u2086\u208b\u2081\u2080, v\u00b9 v\u00b2 independently are c\u2081\u208b\u2086 or alkoxy v\u00b9 and v\u00b2 along with the carbon Atom to which they are United to form a Ring of formula (2), d Where every v\u00b3 and v\u2074 are independently or s, or NH, provided that when one of v\u00b3 and v\u2074 is s, the other is NH,And they are not always v\u00b3 and v\u2074 both NH Q is 1 or 2 each is independently c\u2081\u208b\u2086 v\u2075 alkyl or co\u2082r\u2076\u2070, where each r\u2076\u2070 is independently Hydrogen or alkyl c
