The invention discloses a medicament composition for treating and/or preventing individual gastric ulcer disease or illness, which contains active components with effective amount for treating and pharmaceutically acceptable carrier, wherein the active components are selected from berberine in coptis root and corydalis B in corydalis ambigua, or their pharmaceutically acceptable salt as well as the use of medicament composition. The invention also discloses a method for treating and/or preventing individual gastric ulcer disease or illness, and the method includes steps for giving the composition disclosed in the invention to individual.