Markus RAST,Peter SKUFCA,Wolfram STEINHILBER,Gerhard BECKER,Jurgen VOLZ,Wolfgang ISE
申请号:
US14068074
公开号:
US20140120086A1
申请日:
2013.10.31
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.