Provided is an anti-CD98 antibody-drug conjugate comprising an anti-CD98 antibody, a linker, and a drug, or a pharmacologically acceptable salt of the anti-CD98 antibody-drug congugate, as an anti-tumor drug having exceptional anti-tumor effects and safety as well as exceptional therapeutic effects, wherein: the linker is selected from the group consisting of -(succinimid-3-yl-N)-CH2CH2CH2CH2CH2-C(=O)-GGFG-NH-CH2-O-CH2-C(=O)-, -(succinimid-3-yl-N)-CH2CH2CH2CH2CH2-C(=O)-GGFG-NH-CH2CH2-O-CH2-C(=O)-, and -(succinimid-3-yl-N)-CH2CH2-C(=O)-NH-CH2CH2-O-CH2CH2-O-CH2CH2-C(=O)-GGFG-NH-CH2CH2CH2-C(=O)- the drug is a compound represented by the formula a nitrogen atom of a position-1 amino group of the drug bonds to a carbonyl moiety of the linker and the anti-CD98 antibody bonds to a succinimide moiety of the linker.本發明係提供一種抗CD98抗體-藥物結合物,其係作為抗腫瘤效果與安全性面優異之具有優異治療效果的抗腫瘤藥,包含抗CD98抗體、連接物及藥物之抗CD98抗體-藥物結合物或其藥理學上可容許的鹽,其中連接物為選自包含-(琥珀醯亞胺-3-基-N)-CH2CH2CH2CH2CH2-C(=O)-GGFG-NH-CH2-O-CH2-C(=O)-;-(琥珀醯亞胺-3-基-N)-CH2CH2CH2CH2CH2-C(=O)-GGFG-NH-CH2CH2-O-CH2-C(=O)-;及-(琥珀醯亞胺-3-基-N)-CH2CH2-C(=O)-NH-CH2CH2-O-CH2CH2-O-CH2CH2-C(=O)-GGFG-NH-CH2CH2CH2-C(=O)-的群組的連接物,藥物為下式所表示的化合物,藥物之1位之胺基之氮原子與連接物的羰基部分結合,抗CD98抗體與連接物的琥珀醯亞胺基部分結合。
