Headache treatment methods are described and include providing an energy delivery device locating a secondary or higher-order branch of a postganglionic nerve that provides innervation for a patients head, by identifying a target region of the patients head that includes the nerve branch positioning, within the target region, a portion of the energy delivery device and applying, from the positioned portion of the energy delivery device to the target region, an amount of energy effective to result in a stimulation activity of the nerve branch and, after observing the stimulated nerve branch activity, delivering, from the energy delivery device to the nerve branch, energy in an amount effective to reduce a headache severity in the patient.