PUROHIT, AJAY,HARRIS, THOMAS D.,RADEKE, HEIKE S.,ROBINSON, SIMON P.,YU, MING,CASEBIER, DAVID S.,AZURE, MICHAEL T.
申请号：
CA2673853
公开号：
CA2673853C
申请日:
2007.12.21
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Novel compounds that find use as imaging agents within nuclear medicineapplications (PET imaging) for imaging of cardiac innervation are disclosed.These PETbased radiotracers may exhibit increased stability, decreased NE release(thereby reducingside effects), improved quantitative data, and/or high affinity for VMAT overpriorradiotracers. Methods of using the compounds to image cardiac innervation arealso provided.In some instances the compounds are developed by derivatizing certaincompounds with 18Fin a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers,gamma-propylalkylethers and beta-proplylalkylethers. Alternatively oradditionally, a methyl group ais added to the amine, and/or the catechol functionality is either eliminatedor masked as away of making these compounds more stable. Exemplary compounds include thosehavingthe structure(see above formula)wherein n, R, R1, R2, R3, W, X, Y, and Z are as defined in the description.
