1. A fully human antibody or antigen-binding fragment thereof that binds insulin-like growth factor-II (IGF-II) has a cross-reactivity to insulin-like growth factor I (IGF-I) and neutralizes the activity of IGF-I and IGF-II, where the specified antibody or its binding fragment includes three complementarity determining regions of the heavy chain (HCDR1, HCDR2 and HCDR3) and three complementarity determining regions of the light chain (LCDR1, LCDR2 and LCDR3), where the complementarity determining region of the heavy chain 1 (CDR1) has an amino acid sequence “Ser Tyr Tyr Ser” (SEQ ID NO: 21)； the heavy chain complementarity determining region 2 (CDR2) has the amino acid sequence “Tyr Phe Phe Tyr Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys Ser” (SEQ ID No: 22)； the complementarity determining region 3 of the heavy chain (CDR3) has the amino acid sequence “Ile Thr Gly Thr Thr Lys Gly Gly Met Asp Val” (SEQ ID NO: 23)； the complementarity determining region 1 light chain (CDR1) has the amino acid sequence “Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His "(SEQ ID No: 24)； complementarity determining region 2 light chain (CDR2) having an amino acid sequence awn «Gly Asn Asn Asn Arg Pro Ser» (SEQ ID №: 25)； the complementarity determining region 3 of the heavy chain (CDR3) has the amino acid sequence “Gin Ser Phe Asp Ser Ser Leu Ser Gly Ser Val” (SEQ ID No: 26) .2. An antibody or antigen binding fragment thereof according to claim 1, wherein said antibody is a fully monoclonal antibody. An antibody or antigen binding fragment thereof according to claim 1, wherein said antigen binding fragment is an antigen binding fragment of a fully monoclonal antibody. An antibody or antigen binding fragment thereof according to claim 3, wherein said antigen1. Полностью человеческое антитело или его антигенсвязывающий фрагмент, которые связывают инсулиноподобный фактор роста-II (IGF-II), имеют перекрестную реактивность к инсулиноподобному фактору роста I (IGF-I) и нейтрализуют акт
