The present invention is to obtain capsules which do not disintegrate in stomach and intestine after orally administrating them and which disintegrate specifically in large intestine. The present invention thus provides a capsule which disintegrates specifically in large intestine, comprising a content comprising a main agent, and a shell, covering the content, comprising a natural water-soluble polymer as a shell base material and chitosan powder dispersing in the natural water-soluble polymer.本發明之目的為獲得口服投藥後不會在胃與小腸分解，且特定於大腸分解之膠囊。因此本發明提供一種特定於大腸分解之膠囊，包含有內含主要試劑之內容物，以及包覆該內容物之外殼，該外殼含有作為外殼基材之天然水溶性聚合物，以及分散於該天然水溶性聚合物中之幾丁聚醣粉末。
