#$%^&*AU2015252036A120170518.pdf#####ABSTRACT The present invention relates to methods and compositions for treating a condition associated with, or arising from, astrocyte dysfunction or glial scar formation or progression in an individual. The present invention is useful for, but not limited to, the 5 treatment of central nervous system (CNS) injuries. The present invention provides a method for promoting the recovery of central nervous system function in an individual having CNS injury or damage, the method comprising administering ephrin-A1 to the individual, thereby enhancing recovery of central nervous system function. The present invention also provides a method for minimising glial scarring in an individual having 10 CNS injury or damage, the method comprising administering ephrin-A1 to the individual, thereby minimising glial scarring. The invention also provides a method reducing reactive astrogliosis in an individual having CNS injury or damage, the method comprising administering ephrin-A1 to the individual, thereby reducing reactive astrogliosis. 15
