MCL-1特異性調節的方法與成分

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专利权人:

Dana-Farber Cancer Institute Inc.

发明人:

WALENSKY, Loren, D.,STEWART, Michelle, L.

申请号：

HK12101627.5

公开号：

HK1161272B

申请日:

2012.02.17

申请国别(地区):

HK

年份:

2017

代理人:

摘要：

A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-1 with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-1 are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/