A particle beam irradiation system is provided in which in the multi-energy extraction control operation that realizes change control of an extraction beam energy in a synchrotron (13) within a short time, when ion beam irradiation is halted, an operating cycle is updated within a short time and a dose rate is improved. To this end, operating control data (700) for each of devices constituting the synchrotron (13) is constructed by multi-energy extraction control pattern data (70) for controlling extraction of beams of a plurality of energy levels at one operating cycle, and a plurality of sets of deceleration control data (73a, 73b, 73c) that correspond to the extraction control of the beam of the plurality of energy levels. The devices are controlled by using the operating control data (700) to conduct the extraction control of the beam of the plurality of energy levels, and the plurality of sets of deceleration control data (73a, 73b, 73c) corresponding to the extraction control of the beam of the plurality of energy levels are provided to enable rapid shifting to deceleration control from any extraction energy level.
