A disposable isolation/protective cover for a stethoscope comprising a bell, elongated connector body portion and two ear pieces wherein said isolation/protective cover is sealed on all sides except for the bottom permitting the stethoscope to be inserted therethrough; said cover material is made of acoustically transmitting and viral, bacterial and fluid impermeable material. A flap closes the stethoscope once inserted completely enclosing the stethoscope and preventing exposure of any kind.