MACOMBER LAUREL R.,马柏瑞,馬柏瑞,SOMMERICH, ROBERT E.,锺柏莉,鍾柏莉,SHENOY, VIVEK N.,许依文,許依文,HALVORSEN, MATTHEW J.,洪玫秀
申请号：
TW094103484
公开号：
TWI445521B
申请日:
2005.02.04
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
A collagen device is prepared by mixing collagen with purified water for a period of time sufficient to form a mixture. The pH of the mixture is adjusted to a pH level sufficient to substantial ly solubilize the collagen. A first predetermined amount of the mixture is placed into a container. The mixture is subjected to a lyophilizing process and formed into a collagen device. The collagen device is also cross-linked. The collagen device has a plurality of pores wherein a majority of the pores have a diameter of less than 10 μm. To use the collagen device as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the collagen device is placed in contact with bodily tissue and that contact is maintained until the collagen device is substantially resorbed within the bodily tissue.一膠原器件經由將膠原與純水混合一段足以形成一混合物之時間的方式製備。將該混合物之pH值調整成一足以使膠原實質地溶解的pH值水準。將一份第一預定量的該混合物置入一容器內。使該混合物經歷一凍乾程序並形成一膠原器件。使該膠原器件交聯。該膠原器件具有複數個孔，其中大部分的孔具有一小於10μm的直徑。為使用該膠原器件當作一替換、加固或加強身體組織的植入物，或是當作一黏連障壁，將該膠原器件安置為與身體組織接觸且使此接觸狀態維持到該膠原器件被該身體組織大致地吸收為止。
