BRINKMANN, ULRICH,HOFFMANN, EIKE,DENGL, STEFAN,MAYER, KLAUS
申请号：
CA2930046
公开号：
CA2930046A1
申请日:
2014.12.29
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti- hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.
