NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AND METHODS FOR GENERATING SCAFFOLDS FOR THE USE AGAINST PANCREATIC CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumorassociated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.本發明涉及用於免疫治療方法的肽、蛋白質、核酸和細胞。特別是,本發明涉及癌症的免疫療法。本發明還涉及單獨使用或與其他腫瘤相關肽(刺激抗腫瘤免疫反應或體外刺激 T 細胞和轉入患者的疫苗複合物的活性藥物成分)聯合使用的腫瘤相關 T 細胞 (CTL) 肽表位。與主要組織相容性複合體 (MHC) 分子結合的肽或與此同類的肽也可能是抗體、可溶性 T 細胞受體和其他結合分子的靶標。
