Compositions and Methods for Depleting Mutant p53

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专利权人:

Georgetown University

发明人:

Fung-Lung Chung,Anthony Di Pasqua

申请号：

US13721681

公开号：

US20130158111A1

申请日:

2012.12.20

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention is directed towards methods of treating abnormal tissues in a subject or sensitizing an abnormal tissue to a chemotherapeutic agent. The methods comprise screening at least a portion of an abnormal tissue for at least one mutant form of p53 protein, and administering at least one isothiocyanate (ITC) to the subject or abnormal tissue if the abnormal tissue is positive for the at least one mutant form of p53.

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中国工程科技知识中心

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http://www.ckcest.cn/home/