A compound used to improve diseases caused by aquaporin deficiency, which is 18β-Glycyrrhetinic acid derivative. Said compound can improve diseases caused by aquaporin deficiency, also be able to improve aquaporin (AQP) production and enhance skin function. Since AQP have many advantages in skin cells, for example promoting water and glycerine molecular transportation、increasing the skin elasticity and the cuticle moisture、increasing the cell proliferation and the cell migration, so that it can promote the skin barrier function and the wound cicatrization, therefore said compound can be applied potentially as a medicinal cosmetic in the skin medicine cosmetology, or as a new medical composition to treat the diseases caused by AQP abnormality, such as urine concentration defect、wound healing slow down、corneal re-epithelialization slow down and so on.一種化合物用於改善水分子通道蛋白缺失所引起之疾病，其中該化合物係為18β-甘草次酸衍生物，利用該化合物可促進水分子通道蛋白質(aquaporin，簡稱AQP)形成，提高皮膚功能，由於AQP能促進水分子及甘油的運輸，可增加皮膚彈性與角質層的保濕程度、增加細胞增生及細胞遷移達到促進皮膚障壁功能及傷口癒合之效果，因此該化合物可開發為藥用化妝品應用於皮膚醫學美容之範疇；對於一些因AQP表現異常所導致的疾病，如：尿液濃度濃縮缺陷、傷口癒合減緩、眼睛角膜細胞的重新上皮化減緩，該化合物亦可做為新的治療藥物。
