The present invention is to provide a vascular endothelium growth factor (VEGF) production promotor, a hair papilla cell activator and hair cosmetics having an effect of a full of vascular endothelial growth factor (VEGF) to promote production and hair growth, and stable supplies. In one aspect of the present invention, the VEGF production promotor includes ferment metabolites of Lactococcus lactis subsp. cremoris H-61 clone as an active component. Moreover, the hair papilla cell activator containing the ferment metabolites as an active component have a higher promotion function and thus can exhibit a hair growth effect.本發明提供一種具有充分之血管內皮細胞增殖因子(VEGF)之產生促進及育毛效果且可穩定供給之VEGF產生促進劑、毛乳頭細胞賦活化劑、以及毛髮化妝材料。本發明之一形態之VEGF產生促進劑含有乳酸乳球菌乳脂亞種(Lactococcus lactis subsp.cremoris)H-61株之發酵代謝物作為有效成分。而且,含有上述發酵代謝物作為有效成分之毛乳頭細胞賦活化劑具有較高之VEGF產生促進作用,因此可發揮育毛效果。
