PROBLEM TO BE SOLVED: To provide a peptide being the pathologic condition marker of a disease causing the accumulation of Aβ in the brain of Alzheimers disease, mild cognitive deficit, or the like to provide a DNA encoding the same to provide a method for producing the peptide, to provide an antibody to provide a method for screening a compound bound to the peptide, to provide an examination medicine for the disease, to provide a method for examining the disease, and to provide a remedy thereof.SOLUTION: The peptide comprises a sequence of any one of the following sequences (1)-(3), and being a pathogenic condition marker. (1): TLEIPGNSDPNMIPDGDFNSYVR (DN1), (2): VTASDPLDTLGSEGALSPGGVASLLR (DN2), and (3): TLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLR (DN1+DN2).COPYRIGHT: (C)2013,JPO&INPIT【課題】アルツハイマーや軽度認知障害など脳においてAβの蓄積を生じる疾患の病態マーカーとなるペプチド、それをコードするDNA、ペプチドの製造方法、抗体、ペプチドに結合する化合物のスクリーニング方法、疾患の検査薬、疾患の検査方法、治療薬を提供すること。【解決手段】下記(1)ないし(3)のいずれかの配列から成り、病態マーカーとなることを特徴とするペプチド。(1)TLEIPGNSDPNMIPDGDFNSYVR ‥‥‥(DN1)(2)VTASDPLDTLGSEGALSPGGVASLLR ‥‥‥(DN2)(3)TLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLR ‥‥(DN1+DN2)【選択図】図3
