Nationwide Childrens Hospital;Nationwide Children's Hospital; Inc.
发明人:
Bakaletz, Lauren O.,Munson, Robert S. Jr.
申请号：
AU2004309399
公开号：
AU2004309399B2
申请日:
2004.12.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention described herein relates to regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable (NTHi) and from strains a, b, c, e and f. The invention provides isolated pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to and methods of treating and preventing related pathological conditions.
