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MICRORNA-29B REGULATES VASCULAR SMOOTH MUSCLE CELL PROLIFERATION AND MIGRATION BY INFLAMMATORY CYTOKINE
专利权人:
연세대학교 산학협력단; YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
HWANG, KI CHUL,황기철,HWANG, KI CHULKR
申请号:
KR1020130162205
公开号:
KR1020150074426A
申请日:
2013.12.24
申请国别(地区):
KR
年份:
2015
代理人:
摘要:
The present invention relates to microRNA-29b regulating proliferation and migration of a vascular smooth muscle cell by inflammatory cytokine, which can be used in preventing, diagnosing, or treating abnormal proliferation or motion disease of a vascular smooth muscle cell as inhibiting formation of endangium during blood vessel damage by inhibiting proliferation and migration of a vascular smooth muscle cell induced by IL-3 as microRNA-29b for inhibiting expression of Mc1-1 and MMP2.본 발명은 염증유발 사이토카인에 의한 혈관평활근세포의 증식 및 이동을 조절하는 microRNA-29b에 관한 것으로, microRNA-29b는 Mc1-1과 MMP2의 발현을 억제하여 IL-3에 의해 유도된 혈관평활근세포의 증식과 이동을 억제함으로써 혈관 손상 시 혈관내막 형성을 억제하여 혈관평활근세포의 이상 증식 또는 이동 질환을 예방, 진단, 또는 치료하는데 사용할 수 있다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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