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Pyrazole derivatives, medicinal composition containing them, medicinal use thereof and intermediate for their production
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
FUSHIMI, NOBUHIKO,SHIMIZU, KAZUO,YONEKUBO, SHIGERU,TERANISHI, HIROTAKA,TOMAE, MASAKI,ISAJI, MASAYUKI
申请号:
ES03792760
公开号:
ES2386140T3
申请日:
2003.08.21
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A pyrazole derivative represented by the general formula: wherein R 1 represents a hydrogen atom, a C 1-6 alkyl group, a C 2-6 alkenyl group, a hydroxy group (C 2-6 alkyl), a C 3-7 cycloalkyl group , a group (C1-6 alkyl) substituted with C3-7 cycloalkyl, an aryl group which may have 1 to 3 identical or different substituents selected from the group consisting of a halogen atom, a hydroxy group, an amino group, a C1-6 alkyl group and a C1-6 alkoxy group, or an aryl group (C1-6 alkyl) which may have 1 to 3 identical or different substituents selected from the group consisting of a halogen atom, a hydroxy group , an amino group, a C1-6 alkyl group and a C1-6 alkoxy group in the ring; one of Q and T represents a group represented by the formula: or a group represented by the formula: while the other represents a C1-6 alkyl group, a halo group (C1-6 alkyl), a group (C1-6 alkyl ) substituted with C1-6 alkoxy or a C3-7 cycloalkyl group; R2 represents a hydrogen atom, a halogen atom, a hydroxy group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, a halo group (C1-6 alkyl), a halo group (C1-6 alkoxy), a group (C1-6 alkoxy) substituted with C1-6 alkoxy, a group (C2-6 alkoxy) substituted with C3-7 cycloalkyl or -A-RA, in which A represents a bond simple, an oxygen atom, a methylene group, an ethylene group, -OCH2- or -CH2O-; and RA represents a C3-7 cycloalkyl group, a C2-6 heterocycloalkyl group, an aryl group which may have 1 to 3 identical or different substituents selected from the group consisting of a halogen atom, a hydroxy group, an amino group , a C1-6 alkyl group, a C1-6 alkoxy group, a C2-6 alkenyloxy group, a halo group (C1-6 alkyl), a hydroxy group (C1-6 alkyl), a carboxy group, an alkoxycarbonyl group C2-7, a cyano group and a nitro group, or a heteroaryl group which may have a substituent selected from the group consisting of a halogen atom and a C1-6 alkyl group; X represents a single bond, an oxygen atom or a sulfur atom; Y represents a C1-6
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