According to the invention, a fluid exchange catheter is provided, comprising a proximal end and a distal end, as well as an obligatory lumen (1) having a proximal end (11) and a distal end (12), wherein a lumen wall of the obligatory lumen forms a distal wall portion (13) at the distal end of the obligatory lumen, the distal wall portion comprising at least one lumen opening (15), and wherein the distal wall portion exhibits an unblocking function for removing blockage of the catheter, the unblocking function being implemented by structural means of the distal end of the catheter and/or expansibility of at least the distal wall portion in at least an area surrounding the at least one lumen opening. Further, a process for unblocking a fluid exchange catheter is provided, the fluid exchange catheter having a proximal end and a distal end and comprising an obligatory lumen having a proximal end and a distal end, wherein a lumen wall of the obligatory lumen forms a distal wall portion at the distal end of the obligatory lumen, the distal wall portion comprising at least one lumen opening, and wherein the process comprises the step of controlling infusion and/or aspiration through the obligatory lumen for creating a non-linear motion of the fluid flowing through the at least one opening.