Satoru Yuzawa;Irit Lax;Yarden Opatowsky;Joseph Schlessinger;Yan Yang
发明人:
Joseph Schlessinger,Irit Lax,Satoru Yuzawa,Yarden Opatowsky,Yan Yang
申请号：
US12602235
公开号：
US09273134B2
申请日:
2008.06.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
